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The category nobody owns yet

The first intervention that switches off 90% of the nervous system's workload, while the brain stays awake.

Gravity · Light · Sound · Touch

Floatation-REST is the only modality that removes all four external inputs while the person remains fully conscious. Twenty years of peer-reviewed evidence. A Cohen's d above 2. Now a deployable platform that captures the outcomes data on every session.

Built by Dr. Justin Feinstein, the scientist who authored the published clinical evidence base. Chaired by Tania von der Goltz, who scaled Fresenius Medical Care to €36B+. The first system is already operational in Maui.

$26T Brain capital opportunity at stake (McKinsey / WEF)
$232.2B Annual US economic burden of PTSD
Cohen's d > 2 4× the clinical threshold for a "large" effect on anxiety (PLoS ONE 2018)
$300B+ Annual US burnout cost to employers (Gallup)

Not wellness. Infrastructure.

Floatation-REST is not relaxation. It is the first non-pharmacological intervention that produces a measurable, reproducible shift in the autonomic nervous system inside 90 minutes – with a published effect size four times the clinical threshold for "large." What's been missing is the infrastructure to deploy it at the scale the demand requires. That's what we build.

The macro shift

Brain capital is a $26 trillion category. Nobody has built the infrastructure to deliver it yet.

McKinsey and the World Economic Forum have established brain capital as one of the defining economic frameworks of the next two decades. The argument is no longer whether brain health matters. It's who owns the delivery layer at institutional scale.

$26T

Total global economic opportunity from addressing brain capital – workforce performance, innovation, longevity.

McKinsey Health Institute / World Economic Forum
$8.5T

Annual cost to the global economy from impaired brain health – lost productivity, healthcare burden, disability.

McKinsey Health Institute
$4.4T

Potential annual GDP boost by 2050 from investing in mental health interventions.

McKinsey Health Institute
76%

US workers reporting burnout. Existing solutions remain credibility-without-scale or scale-without-credibility.

2025 workplace surveys
The problem

The infrastructure for recovery hasn't kept pace

The societal burden of chronic stress, anxiety, burnout, and trauma is accelerating. Existing options offer either clinical credibility without scalability – or scalability without clinical depth. Nobody offers both.

01

The PTSD treatment gap

$232.2 billion annual US economic burden of PTSD. 39% of patients do not respond to first-line guideline-recommended therapy. Up to 50% do not respond to CBT specifically.

02

The corporate burnout drag

$5 million per 1,000 employees annually. $300 billion+ in US healthcare costs and lost productivity. 76% of US workers report burnout.

03

The first responder and veteran crisis

30% of first responders develop PTSD or behavioural health conditions. 17.2 veterans die by suicide every day. Federal funding is fragmented; on-site infrastructure is absent.

04

The disaster-response gap

Billion-dollar disasters in the US have risen from 3/year in the 1980s to 27 in 2024. Mental health receives just 1–2% of humanitarian financing despite accounting for 20% of emergency-setting health issues.

Nobody has built the infrastructure layer. That is the gap GCS fills.

Why now

The four forces have converged for the first time

The concept behind nervous system regulation through reduced sensory input has existed since 1954. For seventy years it was held back – by counterculture associations in the 1960s and 70s, by the AIDS-era collapse of shared-water wellness in the 1980s, and by a fragmented recovery as retail wellness operators with no clinical standardisation through the 2000s and 2010s. For the first time in the seventy-year history of this modality, four forces are now aligned simultaneously.

FORCE 01

The clinical evidence is here

Dr. Justin Feinstein's work at the Laureate Institute for Brain Research produced the first peer-reviewed clinical evidence (PLoS ONE, 2018) demonstrating Cohen's d > 2 – an extremely large effect size for anxiety reduction following Floatation-REST. A randomised controlled trial (PLoS ONE, 2023) confirmed safety and feasibility across multiple sessions. This evidence base did not exist before 2018.

FORCE 02

The delivery model left retail

GCS builds modular, deployable systems that go to fire stations, hospitals, military bases, offshore rigs, and disaster zones – not the other way around. The intervention now reaches the populations who need it most, in the environments they already inhabit. This is a fundamentally different business model from a fixed-location retail centre.

FORCE 03

Institutional demand is unprecedented

Institutions are actively procuring non-drug recovery infrastructure. The VA mental health budget is $17.2 billion in FY2025 and growing. 27 billion-dollar disasters in 2024. Over $300 billion a year in employer burnout cost. Behind every line item: 17.2 veterans lost every day. The scale of the unmet need is what changed.

FORCE 04

The regulatory environment has shifted

For the first time, deployment-generated outcomes data can support an FDA medical-device submission. The FDA's December 2025 guidance accepts real-world evidence from digital health technologies and wearables. The January 2026 expansion permits non-invasive physiological measurement under the general wellness pathway. The barrier to building a regulatory asset from field deployments has been significantly lowered.

The science

90% of the nervous system's workload, removed. Brain awake.

External stimuli – gravity, light, sound, and touch – account for approximately 90% of the central nervous system's workload. No other intervention removes all four while the person remains fully conscious. Meditation reduces some inputs, not all. Sensory rooms reduce some stimuli, not gravity. Sleep removes consciousness itself. Floatation-REST is the only environment where the brain stays awake while sensory input collapses to near zero.

Gravity
Light
Sound
Touch
Awake Brain stays conscious

No other intervention shuts off all four external inputs simultaneously while the person remains fully conscious. That single physiological fact is the category.

Cohen's d (anxiety)

> 2 · 4× threshold
The clinical threshold for a "large" effect is 0.8. PLoS ONE 2018 measured an effect size four times above it.

Blood pressure

−10 to −15 pts
Diastolic drop within a single 90-minute session. Frontiers in Neuroscience, 2022.

Brainwaves

Theta · 4–8 Hz
Brain slows into theta state, normally only reached by experienced meditators or at the threshold of sleep.

Heart rate variability

High–freq dominance
Sympathetic spikiness smooths into parasympathetic rhythm. The autonomic shift is measurable in real time.

Cortisol

−22% · 8 sessions
Plasma cortisol drops by roughly a fifth across a course of eight sessions, alongside reductions in subjective stress.

Effect persistence

48+ hrs · single session
Anxiolytic and antidepressant effects persist at least two days after the intervention. Feinstein et al., PLoS ONE 2018.

The published evidence

Twenty years of peer-reviewed clinical research, citable verbatim in any investor or institutional conversation.

PLoS ONE · 2018

Anxiolytic and antidepressant effect of Floatation-REST

50 anxious or depressed participants, 30 controls. Cohen's d > 2 for anxiety reduction. Effects persisted at least 48 hours.

Read on PLoS ONE →
PLoS ONE · 2023 (RCT)

Randomised controlled safety and feasibility trial

Six sessions of Floatation-REST in anxious and depressed individuals. Confirmed safe, well-tolerated, feasible. PTSD subgroup among the most benefited.

Read on PubMed →
Lancet eClinicalMedicine · 2023

Floatation-REST for anorexia nervosa (RCT)

Hospitalised women and girls. Reduced body dissatisfaction and anxiety. Effects sustained at six-month follow-up.

Frontiers in Neuroscience · 2022

Acute cardiovascular effects of Floatation-REST

Significant reduction in blood pressure. Heart rate variability shifted toward parasympathetic dominance during a single 90-minute session.

BMC Complementary Medicine · 2025

Systematic review of 63 Floatation-REST studies (1960–2024)

Approximately 1,800 participants across the body of literature. Overall mean effect size of 1.02 for stress reduction.

Feinstein Lab · ongoing

Interoception research in high-anxiety populations

Heightened interoceptive awareness in individuals with high anxiety sensitivity, suggesting a mechanism for recalibrating the body's internal sensing systems.

"We have had several hundred firefighters use Floatation-REST with impressive results. It's rare to find a treatment with so much potential benefit and so little risk."

Dr. Abby Morris, M.D. – former Medical Director, IAFF Center of Excellence
The platform

Every session generates data. The data doesn't reset. It compounds.

We are not a float company. We are the data platform that will own this category. The pools are how we get the data. Four layers. One compounding moat that no competitor can replicate without starting twenty years earlier.

4

Intelligence

Across populations, the data engine surfaces what works for whom – and becomes the basis for individualised regulation protocols. This is the platform's second regulatory asset (Software as a Medical Device), independent of the hardware.

3

Data Engine

Continuous, non-invasive biomarker capture – heart rate, heart rate variability, blood pressure, breathing rate, brainwave activity. Outcomes tracking. Real-world evidence generation. The FDA's December 2025 guidance now explicitly accepts this kind of data in medical device submissions.

2

Protocols

Standardised, evidence-based nervous system regulation methods. Consistent across every deployment. Built on twenty years of peer-reviewed research and refined through clinical practice.

1

Hardware

Deployable and modular Floatation-REST systems with integrated sensors. Designed for institutional environments and field deployment – not retail. Engineered to preserve the sensory-free experience while capturing clean physiological data.

Every session generates outcomes data. Every deployment compounds the moat. The longer the platform operates, the more defensible the data asset becomes.

The product

One core intervention. Four deployment formats.

Same science. Same data platform. Four distinct markets, sequenced by regulatory readiness and deployment difficulty.

Open-pool rapid-deployment unit, ready for crisis-site installation Available now

Rapid-Deployment Systems

Floatation-REST infrastructure, in a shipping container, on the ground in 48 hours.

Self-contained portable units operational on site within hours of arrival. For disaster zones, military forward operating, humanitarian relief, and first-responder field stations.

Buyer
FEMA · DoD · Red Cross · NGOs
Regulatory
General wellness classification
Revenue
Lease + deployment + certification + data
Permanently-installed modular institutional Floatation-REST chamber Available now

Modular Institutional Systems

The fire-station model. Recovery infrastructure where the workforce already lives.

Permanently installed in fire stations, military bases, corporate campuses, universities, and law-enforcement wellness facilities. Resilience and burnout prevention at institutional scale.

Buyer
Fire chiefs · CHROs · base commanders
Regulatory
General wellness classification
Revenue
System + consumables + certification + data
Clinical Floatation-REST session with integrated biomarker capture sensors Earned through evidence

Modular Clinical Systems

The format that supports the FDA evidence pathway and, once cleared, qualifies for reimbursement.

Installed in hospitals, surgical recovery units, VA facilities, and trauma clinics. Used under medical supervision, contributing to the clinical evidence base that supports a staged regulatory submission.

Buyer
Hospital procurement · VA · academic medical centres
Regulatory
FDA De Novo pathway
Revenue
System + protocols + data + future reimbursement
Compact home-clinical unit concept, sequenced behind regulatory clearance Earned through clearance

Home Clinical Systems

The home-dialysis playbook, applied to nervous system recovery.

Clinician-recommended home units for ongoing nervous system support, contingent on future FDA clearance and reimbursement. The long-term volume play – the Fresenius home model adapted for brain capital infrastructure.

Buyer
Patients (subject to insurance coverage)
Regulatory
FDA cleared + insurance coverage
Revenue
Device + consumables + data + insurance billing
The team

Four people. No fifth needed.

The one who authored the science. The one who scaled Fresenius. The one who's cared for 4,000 firefighters. The one who's been engineering these systems for 25 years. There is no fifth person on Earth needed to build this.

Dr. Justin Feinstein, Ph.D., Founder and Chief Scientific Officer of Global Calm Science
De-risks the science

Dr. Justin Feinstein, Ph.D.

Founder & Chief Scientific Officer

Clinical neuropsychologist. Originator of the published clinical evidence base for Floatation-REST. President, Float Research Collective. Former Director, Float Clinic & Research Center, Laureate Institute for Brain Research.

Tania von der Goltz, Founder and Executive Chair of Global Calm Science
De-risks the execution

Tania von der Goltz

Founder & Executive Chair

27 years strategic healthcare finance at Fresenius Medical Care (€36B+ revenue, 4,000+ dialysis clinics globally). Former SVP Global Financial Strategy. Supervisory board, Carl Zeiss Meditec.

Dr. Abby Morris, M.D., Chief Medical Officer of Global Calm Science
De-risks the beachhead

Dr. Abby Morris, M.D.

Chief Medical Officer

Double board-certified Psychiatry/Neurology and Addiction Medicine. Former Medical Director, IAFF Center of Excellence. Over 4,000 firefighters cared for under her medical leadership for PTSD, anxiety, and addiction.

Toby Stanwell-Smith, Chief Technology Officer of Global Calm Science
De-risks the build

Toby Stanwell-Smith

Chief Technology Officer

25+ years engineering Floatation-REST systems. Design Manager at Floataway – the manufacturer behind the units in every major peer-reviewed clinical trial. Deep expertise in floatation engineering, water treatment, and modular construction.

Where we sit

Five capabilities. One category. We're the only ones holding all five.

Nervous-system regulation today is split across five categories: float operators, consumer wearables, meditation apps, in-clinic neuromodulation, and telehealth therapy. Each owns one piece. None integrate hardware, protocols, data, distribution, and a regulatory pathway in a single institutional offering. That gap is the category GCS is building.

Capability matrix: Global Calm Science vs adjacent categories in nervous-system regulation.
Capability GCS Float operators Consumer wearables Meditation apps In-clinic neuromodulation Telehealth therapy
Deployable to crisis sites
Real-time physiological data in-session
Clinical-grade protocols
Real-world evidence platform
Institutional B2B distribution
Military / first-responder focus
Regulatory pathway active

Fully integrated  ·  Partial  ·  Not part of category model

Regulatory pathway

A staged strategy. Speed-to-market plus long-term optionality.

Launch under general wellness classification (no FDA submission required). Generate real-world evidence through institutional deployments. Pursue medical device classification when the data supports it – keeping both regulatory doors open: hardware (De Novo) and the data platform (Software as a Medical Device).

1
Now – Year 2

General wellness launch

Rapid-Deployment and Modular Institutional systems operate under general wellness classification. First revenue. Field data collection begins under the FDA December 2025 real-world evidence framework.

2
Year 2 – 4

Clinical evidence generation

Modular Clinical deployments begin in partner hospitals and VA facilities. Randomised controlled trials extending the existing peer-reviewed evidence base in anxiety and PTSD populations. Health economics data builds the case for reimbursement.

3
Year 3 – 6

De Novo + SaMD submission

FDA De Novo classification request for the hardware. Software-as-a-Medical-Device submission for the data analytics platform – a second regulatory asset. CPT code application and payer engagement follow.

Precedent: Flow Neuroscience built the first clinically validated at-home brain stimulation device for depression. CE-marked in Europe first, evidence base built through real-world deployment, FDA approval secured in 2025. Their staged trajectory mirrors the Global Calm Science strategy almost exactly – and demonstrates that healthcare investors recognise and back this pattern. The broader transcranial magnetic stimulation category followed a sixteen-year arc from first FDA clearance (2008) to expanded indications across OCD, adolescent depression, and treatment-resistant depression, with insurance coverage following within three to five years of clearance. The same trajectory is available to GCS – and the data engine accelerates every stage of it.
The Maui Calm Project deployable Floatation-REST container facility – multiple modular units inside a shipping container shell, lit and operational
Proof on the ground

On the ground in 48 hours.

The first Rapid-Deployment unit is already operational in Maui – providing free clinical-grade sessions to wildfire survivors and first responders. Built in partnership with the Float Research Collective and Floataway.

Not a research prototype. Field-operational infrastructure for crisis-affected populations. Outcomes data from every session feeds the GCS evidence platform – the regulatory case is built one deployment at a time.

Press Maui Now · Maui News · Rotary Satellite Club of Kīhei–Wailea
The ten-year picture

Global Calm Science is the brain capital infrastructure company.

Ten years from now, a firefighter on shift, a soldier off rotation, a hospital patient before surgery, and a wildfire survivor 48 hours after evacuation all reach the same intervention. That's the picture. Every major hospital system. Every disaster response programme. Every Fortune 500 employer that takes recovery seriously. Standardised across military, first responder, humanitarian, and clinical environments.

Measured at every session. Defended by the evidence base. Owned by no one else.

Get involved

Where would you like to start?

Global Calm Science is in conversation with investors, institutional partners, researchers, clinicians, and journalists who understand what's at stake. Tell us which lane is yours.

Which best describes you?

Tell us a little more.

20-minute investor screening call A partner will respond within one business day with a calendar invitation.

How can we reach you?

Your details stay with the GCS team. We never share or sell your information. We will only contact you about the lane you indicated above.

Thank you.

A member of the Global Calm Science team will be in touch shortly. If you requested data room access, your invitation will arrive at the email address you provided.